Breck leads a wagon train of pioneers through Indian attack, storms, deserts, swollen rivers, down cliffs and so on while looking for the murder of a trapper and falling in love with Ruth.

A wagon train heading west across the great desert runs out of water, and is attacked by Indians. One man -- their last hope -- is sent out to find water.

Two men with questionable pasts, Glyn McLyntock and his friend Cole, lead a wagon-train load of homesteaders from Missouri to the Oregon territory. They establish a settlement outside of Portland and as winter nears, it is necessary for McLyntock and Cole to rescue and deliver food and supplies being held in Portland by corrupt officials. On the trip back to the settlement, up river and over a mountain, Cole engineers a mutiny to divert the supplies to a gold mining camp for a handsome profit.

In the 1860s, five men have been tracking a sixth across Nevada for more than two weeks. They shoot and wound him, but he gets away. They pursue, led by the dour Carver, who will pay them each $1 a day once he's captured. The hunted is Gideon, resourceful, skilled with a knife. Gideon's flight and Carver's hunt require horses, water, and bullets. The course takes them past lone settlers, a wagon train, a rail crew, settlements, and an Indian philosopher. What is the reason for the hunt; what connects Gideon and Carver? What happened at Seraphim Falls?

A story set against the Mountain Meadows Massacre, the film is based upon the tragedy which occurred in Utah in 1857. A group of settlers, traveling on wagons, was murdered by the native Mormons. All together, about 140 souls of men, women and children, were taken. Amidst this, two young lovers-to-be, one a Mormon and the other one of the doomed settlers from Arkansas, develop a relationship in an atmosphere of suspicion and rancor.